Research Summary
Cancer arises from a stepwise accumulation of genetic changes through expansion of the malignant cell clones in the population of pre-malignant cells undergoing the Darwinian selection process. In other words, cancer is an outcome of continuous and random acquisition of the changes in the genomes of individual cells. These modifications gradually and progressively change the phenotype of the normal cell making it more malignant through a loss of an overall stability of genome.
To gain the comprehension of the mechanisms underlying tumor development, a number of high-throughput studies have been and are being performed. My basic interest is in the analyis of the large-scale data, both in the statistical and functional perspectives. Grounded in computational biology and insilico functional genomics, my computational skills have allowed me to better understand the processes involved in genomic organization and evolution, gene expression patterns in general and specifcally during carcinogenesis and its progression.
On the other hand, my research work in biology has also resulted in the design of novel algorithms and software tools in various aspects of computational biosciences. Capability to quickly learn new software packages and proficiency in a wide spectrum of bioinformatics applications and databases enabled me to excel in this field.
