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Selected Peer-Reviewed Publications

  1. Spear M, J. Guo, A. Turner, D. Yu, W. Wang, Xi. Hu, J. Kuhn, Y. Wu. 2014. HIV-1 triggers WAVE2 serine 351 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J. Bio. Chem. 289, 6949-6959

  2. Spear, M., J. Guo, and Y. Wu. 2013. Novel anti-HIV therapeutics targeting chemokine receptors and actin regulatory pathways (Invited review). Immunological Reviews 256, 300-312

  3. Hawley, T. M. Spear, J. Guo, and Y. Wu. 2013. Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents. Cell & Biosciences 3:22

  4. Guo, J., X. Xu, T. Rasheed, D. Yu, H. Liang, F. Yi, T. Hawley, T. Jin, B. Ling, and Y. Wu. 2013. Genistein interferes with SDF-1 and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells. Retrovirology 10:62

  5. Li, Z., J. Guo, Y. Wu, and Q. Zhou. 2012. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nucl. Acids Res. 41, 277-287

  6. Guo, J., X. Xu, W. Yuan, T. Jin, Y. Wu. 2012. HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells. Current HIV Research 19, 636-642

  7. Wu, Y., and M. Spear. 2012. Actin, Arp2/3, and Cofilin/trafficking. Encyclopedia of AIDS edited by Thomas. Hope, Douglas. D. Richman, and Mario Stevenson. Springer (In print)

  8. Wang, W., J. Guo, D. Yu, P. J. Vorster, W. Chen, and Y. Wu. 2012. A dichotomy in cortical actin and chemotactic actin activity between human memory and naive T cells contributes to their differential susceptibility to HIV-1 infection. J. Bio. Chem. 287, 35455-35469

  9. Spear, M. J. Guo, and Y. Wu. 2012. The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology 9:45

  10. Xu, X., J. Guo, P. Vorster, and Y. Wu. 2012. Involvement of LIM Kinase 1 in actin polarization in human CD4 T cells. Involvement of LIM Kinase 1 in actin polarization in human CD4 T cells. Communicative & Integrative Biology 5, 381-383

  11. Guo, J., W. Wang, D. Yu, Y. Wu. 2011. Spinoculation triggers dynamic actin and cofilin activity facilitating HIV infection of transformed and resting CD4 T cells. J. Virol. 85, 9824-33

  12. Vorster, J. P., J. Guo,  A. Yoder, W. Wang, Y. Zheng, X. Xu, D. Yu, Spear, M, Y. Wu. 2011. LIM Kinase 1 Modulates Cortical Actin and CXCR4 Cycling and is Activated by HIV-1 to Initiate Viral Infection. J. Bio. Chem.  286, 12554-12564

  13. Yoder, A., D. Yu, Z. Cai, X. Zhang, J. Guo, and Y. Wu. 2011. Effect of microtubule modulators on HIV-1 infection of transformed and resting CD4 T cells. J. Virol. 85, 3020-3024

  14. Maruyama, T., J. Li, J. P. Vaque, J. E. Konkel, W. Wang, B. Zhang, P. Zhang, B. F. Zamarron, D. Yu, Y. Wu, Y. Zhuang, J. S. Gutkind & W. Chen. 2010. Control of the Differentiation of Regulatory T Cells and TH17 Cells by the DNA-binding Inhibitor Id3. Nature Immunology 12, 86-95

  15. Guo J., C. Enos, Y. Wu. 2010. Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein. J. Vis. Exp. 43, 2198

  16. Wu, Y. 2010. Chemokine Control of HIV Infection: Beyond a Binding Competition. Retrovirology 7:86

  17. Wang, Z., Z. Tang, Y. Zheng, D. Yu, M. Spear, S. R. Iyer, B. Bishop, and Y. Wu. 2010. Development of a Non-integrating Rev-dependent Lentiviral Vector Carrying Diphtheria Toxin A Chain and Human TRAF6 to Target HIV Reservoirs. Gene Therapy 17, 1063-1076

  18. Wu, Y and A. Yoder. 2009. Chemokine Coreceptor Signaling in HIV-1 Infection and Pathogenesis. PLoS Pathogens 5(12): e1000520

  19. Yu, D., W. Wang, A. Yoder, M. Spear and Y. Wu. 2009. The HIV Envelop but not VSV-G Glycoprotein is Capable of Mediating HIV Latent Infection of Resting CD4 T Cells. PLoS Pathogens 5(10): e100633

  20. Iyer, S., D. Yu, A. Biancotto, L. B. Margolis, Y. Wu. 2009. Measurement of HIV-1 Preintegration Transcription Using the Rev-dependent Rev-CEM Cell Reveals a Sizable Transcribing DNA Population Comparable with that of Proviral Templates. J. Virol. 83, 8662-8673

  21. Wu, Y. 2009. The Co-receptor Signaling Model of HIV-1 Pathogenesis in Peripheral CD4 T cells. Retrovirology 6:41 (highly accessed).

  22. Wu, Y. 2009. Chemokine Receptor Signaling and HIV Infection (book chapter), Methods in Molecular Biology: Chemotaxis The humana Press Inc.

  23. Wu, Y., A. Yoder, D. Yu, W. Wang, J. Liu, T. Barrett, D. Wheeler, K. Schlauch. 2008. Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients:  a pilot study. Retrovirology 5:95

  24. Wu, Y. 2008. The second chance story of HIV-1 DNA: Unintegrated? Not a problem! Retrovirology 5:61 (Invited Commentary, highly accessed)

  25. Yoder, A., D. Yu, L. Dong, S. R. Iyer, X. Xu, J. Kelly, J. Liu, W. Wang, P. J. Vorster, L. Agulto, D. A. Stephany, J. N. Cooper,  J. W. Marsh and Y. Wu. 2008. HIV-1 envelope-CXCR4 interaction activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 134, 782-792

  26. Young, J., Z. Tang, Q. Yu, D. Yu, and Y. Wu. 2008. Selective killing of HIV-1-positive macrophages and T cells by a Rev-dependent lentivirus carrying anthrolysin O from Bacillus anthracis. Retrovirology 5:36 (highly accessed)

  27. Kelly, J., H. Beddall, D. Yu, J. W. Marsh and Y. Wu. 2008. Human Macrophages Support Persistent Transcription From Unintegrated HIV-1 DNA. Virology 372, 300-312

  28. Amarnath, S., L. Dong, J. Li, Y. Wu and W. Chen. 2007. Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1 infected human CD4+CD25- T cells. Retrovirology 4:57

  29. Wu, Y., M. H. Beddall and J. W. Marsh 2007. Rev-dependent indicator T cell line. Current HIV Research 5, 394-402

  30. Wu, Y., M. H. Beddall and J. W. Marsh. 2007. Rev-dependent lentiviral expression vector. Retrovirology 4:12 (highly accessed)

  31. Carstens, E. B and Y. Wu. 2007. No single homologous region is essential for DNA replication of the baculovirus Autographa californica multiple nucleopolyhedrovirus. J. Gen. Virol. 88,114-122

  32. Wu, Y. 2004. HIV-1 gene expression: lessons from provirus and non-integrated DNA. Retrovirology 1:13 (highly accessed)

  33. Wu, Y.  and J. Marsh. 2003. Gene transcription in HIV infection. Microbes and Infection 5, 1023-1027

  34. Wu, Y. and J. W. Marsh. 2003. Early transcription from nonintegrated DNA in human immunodeficiency virus infection. J. Virol. 77, 10376-10382

  35. Wu, Y. and J. W. Marsh. 2001. Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA. Science 293, 1503-1506