Chemistry
318 Organic Chemistry
Lab
II
Spring 2020
This syllabus can be found at http://mason.gmu.edu/~sslayden/Lab/index.html
REVISED 5/3/2020 (revisions are shown in red, below)
Important additional course
information is found on the CHEM 318 section of BlackBoard.
Lab Text: J. R. Mohrig, D. G. Alberg, G. E. Hofmeister, P. F. Schatz, and
C. N. Hammond, Laboratory Techniques in Organic Chemistry, 4th edition
(2014).
Lab Manual: S. W. Slayden, R. J. Roth, and W.
M. Stalick, Laboratory
Manual: Organic Chemistry 315, 318 (2017).
Lecture Text: David Klein, Organic Chemistry,
3rd edition.
Videos: Most viewing assignments can be
found at
https://ocw.mit.edu/resources/res-5-0001-digital-lab-techniques-manual-spring-2007/videos
(MIT OpenCourseWare Creative Commons license).
PowerPoint files: Additional notes are posted on
BlackBoard for each laboratory.
CHEM 314 lecture is
a pre- or co-requisite for CHEM 318 lab. If you previously took CHEM 314,
you must have earned at least a C to use it as a pre-requisite for Chem 318. If
you drop or withdraw from CHEM 314, you must also drop/withdraw from CHEM 318.
Add, Drop, and Selective Withdrawal deadlines can be
found at http://registrar.gmu.edu.
It is the responsibility of all students to be familiar
with and adhere to the GMU Honor Code. Please see https://oai.gmu.edu/.
If you are a student with a disability and you need
academic accommodations, please contact Disability Services at 993-2474, http://ds.gmu.edu. All
academic accommodations must be arranged through Disability Services.
Course Schedule
Date |
Experiment
Title |
Reading
Assignment |
Report/Assignment
Due |
Lab 1
Jan 21-27 |
Introduction; safety; check-in |
Lab Manual pp. 1-20
Mohrig ch. 1
|
Regardless of what the
weekly PowerPoint file may say, Reports/Assignments are due on the dates
shown below. |
Lab 2
Jan 28-Feb 3 |
Synthesis
of tert-pentyl chloride |
Lab Manual pp.
71-73
Mohrig pp. 142-143, 149-155, 161-166; section 3.2
Klein pp. 272-274, 305-306, 308
Extraction
video (0-11:25, 14:30-16:40 min)
Review of IR spectroscopy - PowerPoint
|
Safety Quiz
on Bb completed
SDS pages printed (see PowerPoint) |
Lab 3
Feb 4-10 |
Nuclear magnetic resonance spectroscopy (1H-
and 13C-NMR); NMR video
Review of IR spectroscopy |
Lab Manual p. 91
Mohrig ch. 22 (except 22.1-22.3, 22.8, 22.10, pp. 382-391);
23.1-23.2
Mohrig 22.11, 21.1-21.5, 21.7-21.11
PowerPoint
tutorials on Bb
|
Synthesis of t-pentyl chloride |
Lab 4
Feb 11-17 |
Identification of an unknown, part 1
Some sections will do Lab 5 first and Lab 4 the next week. Your instructor should inform you if your section is doing Lab 5 first. |
Lab Manual pp. 113-114; 45-47; 49-51
Mohrig [12.3-12.3a, 12.8],
[13.3-13.4] [22.1, 22.2 (pp. 353-355)]
Simple Distillation video (0-8:41 min)
IR
sample prep video
|
Spectroscopy
assignment I |
Lab 5
Feb 18-24
|
Identification of an unknown, part 2
Meet in GMU NMR Center (PH 18) |
Mohrig
22.1, 22.2 (pp. 353-355)
NMR document
|
|
Lab 6
Feb 25-Mar 2 |
Nitration of methyl benzoate |
Lab Manual pp. 103-106
Mohrig 3.2, 15.2, 15.3, 15.5, 15.8, 9.4, 9.6
Klein pp. 791, 797-798, 812-815
Recrystallization video (9:51-14:33
min)
|
Spectroscopy assignment II |
Lab 7
Mar 3-7, 16 23 |
Bromination of toluene
Nitration of methyl benzoate continued
Spring Break March 9-22 |
Lab Manual pp. 93-100, 49-58
Klein pp. 791-794
M.Pt. video
|
Identification
of an unknown
See Bb for exact due date. |
Lab 8
Mar 17-23
Mar 24-30
|
Note: Lab Week is Tues.-Mon. |
|
Nitration
of methyl benzoate
See Bb for exact due date. |
Lab 9
Mar 30-Apr 4
|
Note: Lab Week is Mon. -Sat.
All LabFlow assignments begin on Monday for all sections.
LabFlow
Chemistry Math, Labware Kit Review
|
All LabFlow work will be due the following Monday.
See LabFlow |
Bromination of Toluene
Report Form - Bromination of Toluene (do not use the one from
the Manual) See Bb for exact due date. |
Lab 10
Apr6-11
|
LabFlow
Identifying Unknowns using IR
|
See LabFlow |
Chemistry Math, Labware Kit Review |
Lab 11
Apr 13-18
|
LabFlow
Using NMR Spectroscopy |
See LabFlow |
Identifying Unknowns using IR |
Lab 12
Apr 20-25
|
LabFlow
Grignard Reaction |
See LabFlow |
Using NMR Spectroscopy |
Lab 13
Apr 27-May 2
|
LabFlow
Synthesis of Banana Oil
|
See LabFlow |
Grignard Reaction |
Lab 14
May 5-11
|
Final Exam - see information on Bb |
|
Synthesis of Banana Oil (Report due by Mon., May 4) |
|