NOTE:Remember
that the material covered on the exams from last semester may not correspond
exactly to the material covered in the current semester.
I. Matching: Choose the BEST answer
from column B for items in column A. USE EACH ANSWER ONLY ONCE (15
points)
| ___ 1. TH1 | A. Secretes IL-4 and IL-10 |
| ___ 2. TH2 | B. Mucin-like addressins |
| ___ 3. IgA | C. Mediates positive selection of T cells |
| ___ 4. IgE | D. Expresses mutated sIg |
| ___ 5. IgG | E. Cytotoxin |
| ___ 6. Lymphoma | F. Mediates negative selection of T cells |
| ___ 7. Granzyme | G. Mediates centrocyte selection |
| ___ 8. Centrocyte | H. Integrins |
| ___ 9. Centroblast | I. Opsonizer |
| ___10. Follicular dendritic cells | J. Large number of malignant cells in blood |
| ___11. Thymic cortical stromal cells | K. Malignant cells found in tissues |
| ___12. Bone marrow derived APCs | L. Bound to mast cells |
| ___13. Leukemia | M. Secretes IFNg and IL-2 |
| ___14. Selectins | N. Viral neutralization |
| ___15. ICAMs | O. Large, rapidly dividing activated B cell |
II. Define the following terms (2
points each)
1. Linked recognition
2. Extravasation
3. Affinity maturation
4. Primary focus
5. Allelic exclusion
6. Mitogen
III. Short but complete answers.
1. The immune response to infection can
be divided into three phases. LIST and DESCRIBE these three phases. Include
A) the duration of each phase, B) the mechanisms and
cells mediating these events and C) the outcome of each
phase (9 points)
2. Describe the events of how dimeric IgA
ends up in body secretions. (6 points)
3. What does ADCC mean? Describe the mechanism.
(6 points)
4. What is meant by T cell priming? Describe
how this occurs. (4 points)
5. How does the outcome of B7 binding CD28
and CTLA-4 differ? (4 points)
6. How do TI and TD antigens differ in
the effect on B cells? (6 points)
7.DescribeTWO experiments that demonstrate
the requirment of the thymus gland for T cell development. (5 points)
8. What is the difference between direct
and indirect mechanisms of tissue damage by pathogens? List and describe
three examples for each mechanism. (8 points)
IV. Essay. Answer ONE (1) of the following questions. Be sure your answer is complete and in the form of an essay. (25 points each)
1. B cells are involved in the humoral immune response. Discuss the development and activation of B cells to plasma cell begining with their development within the bone marrow. Include in your discussion the events, locations, cells and molecules involved in the development and activation of B cells resulting in the production of secreted antibodies.
2. T cells have been described as having
a central role in the adaptive immune response. Discuss the development
and activation of T cells begining with their development within the thymus.
Include in your discussion the phenotype of the developing thymocytes,
as well as the events, locations, cells and molecules and events involved
in the development and activation of the three different armed effector
T cells.
Page updated April 20, 2010