Contact Info

  • Sarah Bui, PhD
    George Mason University     10900 University Blvd.
    Discovery Hall 205
    Manassas, VA 20120
    View on Map

  • Phone: (703) 993-4292

  • Fax: (703) 993-9009

  • Email: sbui4@gmu.edu

Sarah Bui

George Mason University PhD Student (2016-2019)

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    Biography

    Sarah Bui received her undergraduate degree in Biology from Virginia Commonwealth University in 2013, after which she completed a Master's degree in Biology at George Mason University in 2016. Sarah is continuing her studies at GMU in the Biosciences PhD program. She is also NREMT certified and PCA licensed. Sarah was awarded the Elaine Joyce Teaching Award in 2016. She teaches undergraduate lab courses at GMU and has taught 400-level course recitation. She currently serves as Internal VP on the Board of the National Organization of Vietnamese Leaders in DC and is a pulmonary fibrosis advocate.

  • Research

    Sarah's main research is focused on mapping the apoptotic pathways induced by ER stress and mitchondrial damage in IPF fibroblasts. Particularly, she is interested in the role of fibroblast oxidative phosphorylation on the pathogenesis of IPF. In addition, she has investigated the correlation of H. Pylori infection and IPF using patient biopsies. From fresh lung samples, she has isolated human-derived primary cell populations and observed their contrasting behavior under various toxicological challenges. Her previous projects have included a review of the newest developments in the ability to control gene transcription with optogenetics and the expression of a recombinant protein (an interleukin receptor) in HEK-293 cells.

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    • Publications

    Rodriguez LR., Bui SN., Beuschel RT., Ellis E., Liberti EM., Chhina MK., Cannon B., Lemma M., Nathan SD., Grant GM. Curcumin Induced Oxidative Stress Attenuation by N-Acetylcysteine Co-Treatment: a Fibroblast and Epithelial Cell in vitro Study in Idiopathic Pulmonary Fibrosis. Molecular Medicine. 2019 June;25:27.

    Polesskaya O, Baranova A, Bui S, Kondratev N, Nazarenko O, Shapiro T, Nardia FB, Kornienko V, Chandhoke V, Stadler I, Lanzafame R, Myyakishev-Rempel M. Optogenetic Regulation of Transcription. BMC Neuroscience. 2018 April; 19(Suppl 1):12.

    Rodriguez LR., Emblom-Callahan M., Chhina M., Bui SN., Aljeburry B., Tran LH., Novak R., Leema M., Nathan SD., Grant GM. Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibriss Reveals Potential Role for CXCL14/CXCR4. Scientific Reports. 2018 Mar; 8:3983.

    Presented Work

    Bui SN. Paige M, Rodriguez LR, Nathan SD, Grant GM. Mitotropic Nanocarrier for Targetted Drug Delivery in Senescent Idiopathic Pulmonary Fibrosis Fibroblasts. Poster session presented at 2019 ATS Conference; 2019 May 17-22 Dallas, TX.

    Rodriguez LR, Ammar R, Sobieski B, Bui SN., John T, Trujillo G, Nathan SD, Grant GM. RNA Sequencing of IPF Fibroblasts Demonstrates the Impact of in-vitro Isolation Methodology on the Senescent Phenotype Poster session presented at 2019 ATS Conference; 2019 May 17-22 Dallas, TX.

    Doane AJ., Bui SN., Grant GM. Evaluating Differential Mitochondria-Associated Dynamics as a Potential Contributor Towards Increased Apoptotic Resistance in IPF Fibroblasts. Poster session presented at 2019 ISB Systems Biology Symposium; Seattle, WA.

    Bui SN., You Y, Paige M, Nathan SD, Grant GM. Novel Tacrolimus (FK506) Analogue Inhibitys FKBP10: LH2 Collagen Processing in IPF Poster session presented at: American Society of Matrix Biology Biennial Meeting; 2018 October 14-17; Las Vegas, VA

    Bui SN., You Y, Paige M, Nathan SD, Grant GM. FK506-Binding Protein 10 (FKBP10) Dual-Roles as Chaperone and Accessory Proteins in Idiopathic Pulmonary Fibrosis (IPF) fibroblasts ER-stress Resiliency Poster session presented at: Midwestern ER Stress Conference, Northwestern University, February 2018, Chicago IL

    Bui SN., Doane A, Rodriguez LR, Nathan SD, Grant GM. Emerging Evidence for BAX-Inhibitor-1 (BI-1) in Differential Unfolded Protein Response (UPR) in Indiopathic Pulmonary Fibrosis (IPF) Fibroblasts Poster session presented at 2018 ATS Conference; 2018 May 18-23 San Diego, CA.

    Rodriguez LR, Beuschel R, Ellis E, Bui SN., Nathan SD, Grant GM. Does Cytochrome p450 3A4 Catalyzed Metabolism in Pulmonary Fibroblasts Contribute to Oxidative Stress in Idiopathic Pulmonary Fibrosis? Poster session presented at 2018 ATS Conference; 2018 May 18-23 San Diego, CA.

    Tran L, Bui SN., Rodriguez LR, Nathan SD, Grant GM. Acetaminophen and the Extracellular Matrix in Idiopathic Pulmonary Fibrosis Poster session presented at: Pulmonary Fibrosis Foundation Summit 2017; 2017 November 9-11; Nashville, TN

    S. Bui, SD Nathan, S. Khandhar, G. Grant. “Apoptotic Challenge Evokes Differential Response Mechanisms of Idiopathic Pulmonary Fibrosis Fibroblasts” Poster session presented at: 2016 American Thoracic Society International Conference; 2016 May 15-20; San Francisco, CA.

    Rodriguez L, Bui S, Nathan S.D., Mani H., Grant G. "Could infection be a significant factor in IPF?" Poster session presented at: 2016 American Thoracic Society International Conference; 2016 May 15-20; San Francisco, CA.