Rebecca Beuschel
George Mason University
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Rebecca Beuschel came to George Mason University in 2015 from Williamsburg, VA to study Neuroscience and Molecular Biology. From 2016 to 2019, she worked for the Grant Lab as a research assistant. During this time, she also worked as an undergraduate learning assistant for several biology courses and with OSCAR, the Honors College, and with Housing and Residence Life. Rebecca is at the NIH on a 2-year post-baccalaureate fellowship in the National Institute of Allergy and Infectious Diseases.
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Rebecca was a highly productive member of the lab who has recently moved on to a research position at the NIH. During her time in the Grant lab Rebecca first started by looking at regulatory elements that were seen in the Cytochrome P450 gene of IPF derived fibroblasts. Her work was a key to the identification of the increased sensitivity that IPF derived fibroblasts demonstrate to curcumin. In addition to this Rebecca also participated in the identification and characterization of dysregulated mitochondrial transcription in IPF patients who are not responding to treatment. Before leaving for the NIH Rebecca has recently validated the humanized mouse model of IPF that the lab will be using to test all significant in-vitro studies
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Manuscripts
Rodriguez LR., Bui SN., Beuschel RT., Ellis E., Liberti EM., Chhina MK., Cannon B., Lemma M., Nathan SD., Grant GM. Curcumin Induced Oxidative Stress Attenuation by N-Acetylcysteine Co-Treatment: a Fibroblast and Epithelial Cell in vitro study in Idiopathic Pulmonary Fibrosis. Molecular Medicine. 2019 June;25:27.
Posters
Beuschel RT., Rodriguez LR., Bui S., Kaler M., Barochia A., Alqawba M., Levine S., Diawara N., Nathan SD., Grant GM. Identification of Novel Biomarkers in the Peripheral Blood of Patients with Idiopathic Pulmonary Fibrosis Poster session presented at: GCURS Rice University; 2018 September; Houston, TX. ; National Collegiate Honors Council Meeting Boston College; 2018 November 7-11; Boston MA.
Rodriguez LR, Beuschel R, Ellis E, Bui S, Nathan SD, Grant GM. Does Cytochrome p450 3A4 Catalyzed Metabolism in Pulmonary Fibroblasts Contribute to Oxidative Stress in Idiopathic Pulmonary Fibrosis? Poster session presented at 2018 ATS Conference; 2018 May 18-23 San Diego, CA.
Beuschnel R., Rodriguez L., Bui S., Aljeburry B., Nathan S.D.,Grant GM. Epigenetic changes in the Promoter regions of Cytochrome P450 2B6 and 3A4 in Idiopathic Pulmonary Fibrosis Fibroblast Derived DNA.Pulmonary Fibrosis Summit. Tennessee, November 2017.
R Beuschel, E. Ellis, LR Rodriguez, S Bui, S.D. Nathan, GM Grant. Impact of a Three-Dimensional Tissue Culture Model on the Transcription of Disease-Specific Genes in Pulmonary Fibroblasts Derived from Patients with Idiopathic Pulmonary Fibrosis. George Mason University Celebration of Scholarship May 2017.
R Beuschel, L Rodriguez, G Grant. Identification of Mutations Within the Regulatory Elements of Cytochrome p450 Proteins in Fibroblast Cells with Idiopathic Pulmonary Fibrosis. George Mason University Celebration of Scholarship May 2015.
