To View a Steric energy comparison of Kanamycin A when it is complexed with the protien vs. it's free gas phase, Click Here.
A comparison overlay of the structures of free Kanmaycin A, with that of the Hetro compound
For a more detailed look at the specific interactions of Kanamycin A and it's protien, Click Here.
PDB ID: 1M4I Vetting, M.W., Hegde, S.S., Javid-Majd, F., Blanchard, J.S., Roderick, S.L. Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates. Nat.Struct.Biol. v9 pp.653-658 , 2002